Side effects are rare and typically mild, sometimes including transient changes in sleep patterns as circadian rhythms adjust
The ability of an antibody to neutralize in vitro is probably the best-known predictor of its antiviral efficacy in vivo
2.1.4.1 The engineering continuum: coupling constraint to functional agnosticism Virus-like particle functionalization strategies can be conceptualized along a continuum defined by the degree of thermodynamic coupling between scaffold assembly and antigen incorporation: Genetic fusion (the fully coupled regime): this remains the most structurally deterministic strategy, ensuring strict 1:1 stoichiometry and genetic stability

Disclosure of interest: Nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P355 - ESOC25-189 VESSEL WALL ENHANCEMENT IN TERMINAL OF INTERNAL CAROTID ARTERY WAS DECREASED AFTER DIRECT BYPASS SURGERY FOR MOYAMOYA DISEASE Daizo Ishii 1 , Takeshi Hara 1 , Masashi Kuwabara 1 , Hiroshi Kondo 1 , Shinji Kume 2 , Nobutaka Horie 1 1 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2 Hiroshima University Hospital, Hiroshima, Japan Background and Aims: Intracranial vessel wall enhancement (VWE) on MR imaging is associated with progression and poor outcome in moyamoya disease (MMD)