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Beyond receptor-mediated signaling, BHB mediates post-translational modifications by, e.g., inhibiting class I histone deacetylases, leading to increased histone acetylation and transcriptional activation of antioxidant and mitochondrial regulators such as peroxisome proliferator-activated receptor coactivator 1- (PGC-1) [37, 46]

Administer into the muscle tissue of the hind leg or on the side of the neck of each animal within the first three days of life using a 15mm x 19 gauge needle

Best results: AOD 9604 works best when combined with adequate protein intake and a resistance training program, which preserves the lean mass the GLP-1 drugs tend to erode

J.et al (2011a)