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Functional enrichment showed that KEGG and GO (BP) were both focused on the cell cycle (Fig

Also, in type 2 diabetes mellitus patients, impaired zinc homeostasis leads to uncontrolled expression of immune mediators, such as IL-1, IL-6, and NF-B, which at the same time simultaneously exacerbate the immune response and lead to pathogenesis, negatively affecting -cells

Subsequently, the mitochondrial morphology in the FAC-treated group underwent changes characteristic of ferroptosis, with mitochondria becoming smaller and rounder and cristae beginning to disappear (Fig

BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance By Modulating Surface Expression of CXCR4