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In addition, methylation also keeps certain genes from turning on

Refueling the Trp biosynthetic pathway by expressing the TRP1 gene could rescue the depletion of the kynurenine pathway intermediates

MitoQ, DPI and the double drug combination decreased the expression of cyclin D1 (G1/S-phase) and cyclin B1 (G2/M phase), suggesting an inhibitory effect on cell cycle progression