doi: 10.1158/1535-7163.MCT-17-0365 119 LiuSKCoackleyCKrauseMJalaliFChanNBristowRG
Acetylation can also regulate the choice between the double-strand break (DSB) repair pathways of non-homologous end joining (NHEJ) and homology-directed repair (HDR) by promoting the recruitment of TP53-binding protein 1 (53BP1) to sites of DNA damage through the modulation of NHEJ [38]
Such findings support a close link between oxidative damage and neuronal injury ( + , a metabolite transported into dopaminergic neurons via the dopamine transporter, accumulates in the mitochondria and inhibits complex I activity of the electron transport chain, reducing ATP production and increasing ROS release, ultimately causing degeneration of dopaminergic neurons in the substantia nigra and striatum ( 2.4 Relationship between aging and neurodegenerative diseases Given the high prevalence of neurodegenerative diseases in older adults, aging is considered the primary risk factor for neurodegeneration ( Beyond AD and PD, numerous other neurodegenerative diseases show strong associations with cellular senescence
29 Popular antioxidants in this system include enzymes that repair damaged DNA (polymerases, glycosylases, and nucleases), along with proteolytic enzymes (proteinases, proteases, and peptidases)
