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2.2 Data acquisition MRI: All data were collected on a Philips 3T Ingenia Elition RX scanner (Philips Healthcare, Best, the Netherlands) equipped with a 32-channel receive-only head coil

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Ethical and bias considerations Ethical standards in sourced studies: The ethical standards of the studies referenced were considered, particularly for human and animal trials

Hence, CS exposure may additionally initiate abnormal ECM remodeling process, a well-established hallmark of COPD 49,50,51