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Direct Exposure to Ammonia and Hyperammonemia Increase the Extracellular Accumulation and Degradation of AstrogliaDerived Glutathione in the Rat Prefrontal Cortex. Toxicological Sciences 117: 163168

4 Oxidative stress and AD The pathophysiology of AD is multifaceted, and impaired aortic integrity is a fundamental mechanism in the pathology of AD, which results from the inherent instability of the aortic wall (e.g., due to inherited connective tissue diseases) or acquired conditions (e.g., atherosclerotic degeneration associated with aging) (64)