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97,98,99 HFpEF constitutes approximately half of all heart failure cases, particularly in T2D, and is defined by a left ventricular ejection fraction 50% with predominant exercise intolerance

These behavioral abnormalities are exacerbated by social isolation and associated with deficits of social memory, spatial working memory and prepulse inhibition ( Animal models of poor motivation of SCZ are represented by the DA deficient mice induced, for example, with local neurotoxic injection with 6-OHDA in nucleus accumbens, mutant rodents with an overexpression of DA D2R (DR2-OE) or an overexpression of DA D3R (DR3-OE)

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