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By providing an unmethylated blend of adenosylcobalamin and hydroxycobalamin, this supplement supports the underlying methylation cycleensuring the HNMT enzyme has what it needs to break down histaminewithout forcing the aggressive, rapid methylation that causes mast cells to degranulate

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Patch clamping was carried out using an EPC-10 amplifier and a PatchMaster software (HEKA, Lambrecht, Germany)