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However, BDNF deliver into the brain of transgenic APP/PS1 mice using ADTC5 as BBB modulator in a mouse model for AD

After being blocked with 5% dry milk in TBST, the sections were probed overnight at 4 C with primary antibodies against Collagen I (1:800), PGC-1 (1:1000), Nrf1 (1:200), Tim23 (1:50), Drp1 (1:200), P-Drp1ser616 (1:1000), ACSL4 (1:100), FTH1 (1:200), GPX4 (1:2000), TFR1 (1:500), Nrf2 (1:200), P-MLKL (1:200), GSDMD-N (1:200), Cleaved caspase-3 (1:50) and -SMA (1:2000)

X.ZhouY.ZhangC

In addition, the classical metabolic drug metformin increases oocyte maturation rate and early embryonic developmental potential in aged mice cultured in an in vitro maturation system through a mechanism involving SIRT3-mediated deacetylation of SOD2, which mitigates mitochondrial damage [362]