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Iglehart I, Lederman S, Kelley M, Vaughn B, Engels J, Sullivan G.POS0324 TARGETING NON-RESTORATIVE SLEEP IN FIBROMYALGIA WITH BEDTIME TNX-102SL (SUBLINGUAL CYCLOBENZAPRINE HCL) SIGNIFICANTLY IMPROVES PAIN INRESILIENT, A CONFIRMATORY PHASE 3 RANDOMIZED CLINICAL TRIAL

Research Dose Ranges Preclinical animal studies: 110 mcg/kg (nanogram to microgram range) once or twice daily Extrapolated human equivalent range commonly discussed in clinical literature: 200500 mcg/day Human pilot IV data: doses up to 20 mg were tolerated without adverse effects in two healthy adults (Lee & Burgess, 2025) though this is far above typical outpatient dosing Protocol: Musculoskeletal / Connective Tissue Healing For tendon, ligament, or muscle injury recovery, the standard approach in clinical functional medicine practice involves: SubQ injection at 200500 mcg once daily , injected near (not into) the injury site Cycle length: typically 48 weeks , with reassessment Often combined with TB-500 (thymosin beta-4) for synergistic tissue remodeling the BPC+TB stack Best results seen alongside physical therapy, not as a substitute for it Protocol: Gut and GI Mucosal Healing For IBD, gut permeability, NSAID damage, or H

55, 109 Other studies in man have shown a slight pressor response after infusion of a higher dose of Ang-(17) in healthy volunteers, 151 whereas infusion into the brachial artery of patients with heart failure treated with an ACE inhibitor did not induce significant forearm blood flow changes