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Asthma Patients suffering from asthma change NO withdrawal as a result of displaced oxygen within the alveoli, asphyxiation, bronchospasms, and a 6 20% reduction in diffusing capacity after repeatedly inhaling psychoactive substances, leading to [17]: GPs are likely to be consulted, and hospital care may be arranged for patients with severe asthma exacerbated by NO abuse due to requirements for mechanical ventilation, chest x-rays, and 24-hour monitoring to manage severe hypoxia (SpO2 25 breaths/min) [18]