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It notably diminishes the weak intermolecular interactions and improves proteinwater interactions, which deter the aggregation of RBPs and promote the dissolution of the preformed fibril aggregation 82,93,94

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At day 6 after the first infusion, the semaglutide-treated and GLP-1MK-801-treated mice were crossed-over in terms of treatment and administered with another single infusion of either GLP-1MK-801 (0.22 nmol, 2 l) and semaglutide (0.22 nmol, 2 l), respectively, while vehicle-treated mice received vehicle treatment once again