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Description

SAC inhibits TGF-1induced myofibroblast differentiation, downregulates AKT/NF-B signaling, and preserves thiol homeostasis

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In order to get insights about such hypothesis, Blanger and collaborators manipulated glucose utilization in neuronal cultures taking advantage of the observation made by Herrero-Mendez and collaborators that overexpression of Pfkfb3 results in an increased glycolytic rate in cultured rat neurons (Herrero-Mendez et al., 2009)

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Metalloproteinases in melanoma

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In this 12-week, randomised, double-blind, placebo-controlled, multicentre trial in 279 individuals with MS, the Cannabis extract (maximum daily delta-9-THC dose = 25 mg/day) produced highly significant reductions in muscle stiffness, muscle spasms, and pain relative to placebo together improved sleep quality that was evident at week-4 and maintained throughout the trial

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