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Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of phospholipid hydroperoxide glutathione peroxidase -an enzyme present in spermatids -which becomes a structural protein in the mid-piece of mature spermatozoa

Supplementing the cell lines with alanine or minimal essential medium had no effect on viability in bortezomib-treated INA-6 or ANBL-6 cells (Supplementary Figure S1A)

It is worth mentioning that recent studies have found that endoplasmic reticulum stress response plays an important role in ferroptosis

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