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Moreover, Ras induces Ras-related C3 botulinum toxin substrate 1 (Rac1), which in turn leads to further stimulation of p38 MAPK and JNK (Trusolino et al., 2010)

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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (488), contradicting the hypothesis that ME/CFS could be caused by a clearance failure of the pathogenic microbe (99, 107)