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The choice between them boils down to what the medications guidelines require and patient safety considerations: Use sterile (preservative-free) water when indicated for sensitive situations (newborns, intrathecal use, single-dose needs), and use bacteriostatic water when a multi-dose solution is needed and its safe to do so

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Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC