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Figure 5: Atherosclerosis-related vascular inflammation involves artery thickening (plaque buildup), oxidized LDL cholesterol, and platelet-induced clot formation

An siRNA approach has also been applied to circulating angiogenic cells and showed that a 50% silencing of the GLA gene is enough to significantly impact their migration capacity [58] To shed light on the mechanism by which -Gal A deficiency leads to another commonly observed Fabry disease phenotype, namely neuronal dysfunction, Kaneski et al