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doi: 10.3389/fendo.2022.945578 Received 16 May 2022 Accepted 05 October 2022 Published 20 October 2022 Volume 13 - 2022 Edited by Tiziano Baroni, University of Perugia, Italy Reviewed by Sahar Houshdaran, University of California, San Francisco, United States

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In pancreatic cancer cells, glutamine supports the production of NADPH via a noncanonical metabolic pathway 29 , and the mitochondrial glutamine transporter is strongly associated with glutaminolysis-induced NADPH generation 16