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SA, in either plasma or urine, should be below detectable limits (or within the limits of normal established by the reference laboratory)

Oxid Med Cell Longev 2017:132

This is the mechanistic reason researchers study it separately from native IGF-1: with less protein-binding interference, the analog remains bioavailable roughly 3x longer, giving it an extended half-life of approximately 2030 hours compared to native IGF-1s 1215 hours