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Moreover, activation of proinflammatory signaling pathways also induces the production of immunomodulatory lipid mediators, including those from eicosanoid metabolism, through upregulation of the expression of eicosanoid enzymes such as cyclooxygenases (COXs) and lipoxygenases (LOXs) and their respective bioactive lipid products, prostaglandins (PG), thromboxanes, and leukotriene B4 (LTB 4 ) [2]

At present, the available human evidence is supportive but incomplete

To determine whether VRK2 has an influence on the interaction of SLC7A11 and Sec24C, we checked the affinity of SLC7A11 and Sec24C in VRK2-WT and VRK2-KO cells

These findings support the role of obesity treatment in managing GERD (Reference Krner, Corts and Lukens59)