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FDA immunogenicity flag for compounded forms Option Selank Primary research focus Anxiolytic / GABAergic gene expression, stress modulation Typical route Intranasal (most discussed) Subjective profile Calmer, anxiety-reducing Main caution FDA Category 2 history (separate listing) Option Caffeine + L-theanine Primary research focus Alertness + smoothing Typical route Oral Subjective profile Stimulant + relaxation Main caution Tolerance, sleep disruption Option Modafinil Primary research focus Wakefulness promotion Typical route Oral, prescription Subjective profile Strong wakefulness, less direct cognition Main caution Prescription-only

(PubMed) Shearer MJ, Newman P

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Khalili et al ., [] who provided oral L-carnitine, found no significant reduction in POAF