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In contrast, spontaneous calcium spikes in astrocytes do not trigger a similar response, suggesting that astrocytic metabolism is mainly focused on meeting high metabolic demands of neurons (104, 105)

In a study that applied EULAR/ACR classification criteria to a cohort of 110 CADM patients, 26.3% did not meet the minimum probability cutoff for DM classification

Collectively, these multi-mode readers combine high-quality measurements with miniaturized assays, short measurement times, and offer considerable savings on materials and other resources

One of the most promising is Survodutide (BI 456906), a peptide currently in late-stage clinical trials