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Med (basel, Switzerland) 6:85

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However, when glutamate accumulates outside the synapse, it activates extrasynaptic NMDA receptors, which suppress CREB signaling and initiate neurotoxic cascades, in contrast to synaptic NMDA receptors that promote survival and plasticity (128, 129), This receptor-location-dependent signaling shift contributes to dendritic atrophy and functional decline observed in stress-related disorders such as depression

The Nrf2 pathway, a major antioxidative mechanism in astrocytes, also becomes dysregulated during neurodegeneration