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10.3389/fcvm.2022.1057985 180 XiaoJ.LiN.XiaoS.WuY.LiuH

Analogous to its role in adipocytes, GPR81 activation in cancer cells decreases intracellular cAMP and suppresses proteinkinase A (PKA) activity, thereby modulating lipid remodeling (55,56)

Oridinon (Ori), a natural terpenoid derived from the plant Isodon rubescens (Hemsl.), can increase cardiac Gln levels and inhibit the decline of ATP/ADP ratio, protecting cardiomyocytes and reducing infarct size in a rat model of myocardial injury