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The requirement for increased nAb concentration to inhibit cellcell spread may be associated with avidity effects of extended cell surfaces interacting with one another (in contrast to a viral surface with potentially less available surface for interaction), although other factors such as the restricted access of nAbs to interacting cell surfaces could also contribute 74,75

In the context of IFN- deficiency, IL-4 exerts a suppressive effect on ABC differentiation, and targeted inhibition of IFN- or IL-21 represents a potential therapeutic avenue

K., Vullo, D., Vooijs, M., Supuran, C

To treat them, you'll probably need shots of vitamin B12 at first, and then you may need to keep getting shots, or taking high doses of a supplement by mouth or nasally