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The latter report suggests that lipid membrane fragments and distorted organelles, together with a non-fibrillar form of Syn, are the main structural components of LBs and that they do not contain fibrillar Syn aggregates

2 Specifically, abnormalities in methylation, including methylation metabolites such as methionine, S-adenosyl-L-methionine (SAM) and S-adenosyl-L-homocysteine (SAH) are present in this population

That study revealed that ferrylHb but not Hb or metHb induce active IL-1 production in LPS-primed macrophages in an NLRP3-dependent manner ( Hemorrhage-Associated Macrophage Subsets Besides the two extreme canonical macrophage phenotypes, the pro-inflammatory M1 and the anti-inflammatory M2, many other specific and distinct macrophage subsets exist (103)