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The PPP is one of the three main ways the body creates molecules with One of the uses of NADPH in the cell is to prevent oxidative stress

Hindricks G, Potpara T, Dagres N, et al

Similarly, ER-mitochondria associations and VAPB-PTPIP51 interactions are disrupted by ALS-associated mutant FUS (Stoica et al., 2016), which results in increased production of ROS