glutathione peroxidase breast cancer 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis - Liu - 2021 - Clinical and Translational Medicine Oxidative Stress in Breast Cancer:

Gorman, GS, Chinnery, PF, DiMauro, S, Hirano, M, Koga, Y, McFarland, R, Suomalainen, A, Thorburn, DR, Zeviani, M, Turnbull, DM 2016, Mitochondrial diseases, Nature Reviews Disease Primers , vol

Briefly, DSPE-PEG2000-COOH (233 mg, 0.08 mmol), PyBop (52.04 mg, 0.1 mmol), HOBT (15.31 mg, 0.1 mmol) and DIPEA (38.77 mg, 0.3 mmol) were dissolved in 15 mL anhydrous THF and stirred at room temperature for 4 h under nitrogen stream

Second, the liver enzyme CYP2E1 breaks down about 5-10% of the drug, resulting in the formation of a toxin known as NAPQI

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