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doi: 10.18632/oncotarget.4059 51

These observations underscore the essential role of Sirt1 in mediating NNMTs regulatory effect on glucose metabolism

High-throughput virtual screen for potential METTL5 inhibitors For the target protein, the crystal structure obtained from the PDB database ( was preprocessed by removing water molecules and miscellaneous atoms from the protein structure, protonation to add hydrogen atoms, and the use of the existing ligand SAM in the protein to define the binding site