treatment of melanotic macule Mystery behind labial and oral macules: Clinical, dermoscopic and pathological aspects Laugier-Hunziker syndrome Treatment of labial melanotic macules

N Engl J Med 2011;365:1781-1789

I went from months of broken sleep and compromised shoulder function to fully pain-free and back in training

BrouwerRMKleinMGrasbyKLSchnackHGJahanshadNTeeuwJet al

Alternative TB-500 protocols for different goals Daily low-dose protocol For patients who prefer more frequent, lower-volume injections: Dose: 750 mcg 1 mg daily , subcutaneous Duration: 12 weeks continuous, then 4 weeks off Provides steady-state tissue levels without peaks and troughs of twice-weekly dosing Preferred by some patients with needle anxiety (smaller volume per injection) Body-weight-based TB-500 dosing Some practitioners calculate by weight for greater precision: Loading: 3060 mcg/kg per injection , twice weekly Maintenance: 30 mcg/kg once weekly For a 75 kg patient: loading = 2.254.5 mg per injection