Caligiore et al., in vivo studies also linked the damage to the noradrenergic neurons in the locus coeruleus in the early stage of PD and the dopaminergic neurons in the substantia nigra pars compacta with the contribution of the motor deficits seen in PD patients (Fearnley and Lees, 1993
doi:10.1136/bmj.333.7564.385
I havent weighed myself but my pants are fitting a bit more loosely
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