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J Appl Anim Res 42:166176 Jasek-Gajda E, Jurkowska H, Jasinska M, Lis GJ (2020) Targeting the MAPK/ERK and PI3K/AKT signaling pathways affects NRF2, Trx and GSH antioxidant systems in leukemia cells

Therapeutic outcomes from studies exploring strategies to enhance the bioavailability of papaya and carrot extracts, for instance, by coadministration with other bioenhancers or by preparation of nanoformulations, will be improved

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However, combined treatment of cells with BafA1 and commercial chemotherapeutics (arsenic trioxide (ATO), retinoic acid (ATRA), or araC) induced leukemic cell death, indicating a potential for therapeutic application (148, 149)