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Most MS patients, over time and aging, switch to a progressive phase characterized by a gradual clinical decline with progressive deterioration of neurological functions, due to continuous axonal degeneration ( The mechanism of MS pathology involves complex interactions between systems and cell types, such as neurons, glia, and immune cells, which lead to focal lesions of inflammatory demyelination and widespread neurodegeneration in the brain and spinal cord

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Therefore, the development of new drug delivery systems for SIN, aimed at achieving sustained release, reducing clinical dosages, increasing drug concentrations in the brain, and improving therapeutic outcomes, is of significant importance