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doi: 10.4161/cc.26193 18 McBrayerSKChengJCSinghalSKrettNRosenSTShanmugamM

Separately, GHK-Cu has been found to stimulate fibroblast proliferation while upregulating genes for collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural components of the skin's extracellular matrix and to modulate matrix metalloproteinases (MMPs) and their inhibitors, which supports balanced remodeling rather than excessive breakdown or fibrosis

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A short-term 2017 study, however, did not find that intranasal GSH produced better results than a placebo effect, which turned out to be quite high