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Diabetes Care 22:20942095 Izumino K, Sakamaki H, Ishibashi M, Takino H, Yamasaki H, Yamaguchi Y, Chikuba N, Matsumoto K, Akazawa S, Tokuyama K, et al (1997) Troglitazone ameliorates insulin resistance in patients with Werners syndrome

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Environmental and behavioral factors also heavily influence outcomes: patients who developed durable habit changes during treatment (structured meal timing, exercise consistency, stress management) regain weight more slowly than those who relied entirely on medication's appetite suppression