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doi: 10.1016/j.tim.2017.06.004 76 RusuIGSuharoschiRVodnarDCPopCRSocaciSAVulturarRet al

12 January 1998

Similar content being viewed by others Background Sodium valproate (VPA), a synthetic 2-propylpentanoic acid, is widely used as an antiepileptic, mood-stabilizer, antipsychotic, anti-migraine and analgesic drug [1]

In our recent studies, we have identified a different inhibition mechanism of TGR in which an inhibitor binds non-covalently at the so-called doorstop pocket interfering with enzyme function 33,34