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Studies also examine synaptic-plasticity mechanisms and angiotensin-derived peptide signaling across in-vitro and ex-vivo research systems

One aspect of the invention pertains to the administration of one or more NNMT inhibitors by, for example, contacting one or more cells of an animal to: (a) treat and/or prevent muscular disorders, including, but not limited to, sarcopenia, muscle atrophy, Duchenne muscular dystrophy, Becker muscular dystrophy, Limb-girdle muscular dystrophies, Pompe disease, cardiac myopathies, pulmonary disorders

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Constipation affects a significant percentage of patients