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Muscle Function and Regenerative Research NNMT is also expressed in skeletal muscle, and 5-Amino-1MQ has been utilized to examine NNMTs role in muscle energetics and repair

In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

Blood pressure changes were not observed in clinical trials

That being said, calculating an AHK-Cu injection dosage is guesswork without any published pharmacokinetic data for injectable AHK-Cu