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(2002) wrote: The potent physiologic antioxidant actions of bilirubin reflect an amplification cycle whereby bilirubin, acting as an antioxidant, is itself oxidized to biliverdin and then recycled by biliverdin reductase back to bilirubin

Early recognition, prompt discontinuation of suspected agents, and timely initiation of supportive and immunomodulatory treatment are critical for improving outcomes

Biometal Sci

Potential mechanisms include: Alterations in methylation pathways Changes in NAD+ availability Mild dehydration secondary to metabolic shifts Headaches are generally mild but may become persistent in sensitive individuals