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Biochemically, C4A exhibits higher affinity for amino groups, whereas C4B binds more readily to hydroxyl groups, suggesting that C4A may be more involved in binding immune complexes and protein antigens, while C4B plays a more important role in binding carbohydrate-rich microbial antigens (145)

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The vasodilatory actions of NO play a prominent role in this process (143)

At higher doses (200 mg/kg), RA decreased MDA and MPO, restored GSH levels, enhanced SOD activity, reduced IL-1 and TNF- levels, and also modulated T cell populations, reducing mRNA transcription of inflammatory markers, and enhanced gene expression and positive cell staining for MUC-2 and ZO-1