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525-0401) taking care not to aspirate from the buffy coat layer between the plasma and the erythrocytes, either by automated script on a TECAN liquid handling platform (Freedom EVO, TECAN) or manually with sterile serological pipettes

Early symptoms are mild and often go undetected until the disease progresses, at which point management of symptoms becomes the primary standard of care

Variation in redox state, as represented by the intracellular GSH:GSSG ratio, can have profound clinical implications, enhancing cell signalling and even cell death