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Interestingly, it was reported that during natural sleep or while under anesthesia, the interstitial space increased by 60%, resulting in a prominent rise in the convective exchange of cerebrospinal fluid and interstitial fluid (Xie et al., 2013

Ultimately, future studies investigating the exact molecular pathways involved in the response to stress (including Nrf2/NF-B cross-talk), intestinal barrier function, and the immune system in stressed broiler chickens would be very valuable

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