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This enzyme requires the FAD coenzyme form of riboflavin for this reduction reaction, thus, emphasizing the role of riboflavin in the formation of reduced, active, glutathione ( Second, it has been shown that the oxidation of dihydroriboflavin, the reduced riboflavin, forming oxidized riboflavin can deactivate lipid peroxides, emphasizing the independent antioxidant property of riboflavin ( Third, riboflavin effects on antioxidant enzymes activities, including superoxide dismutase (SOD) ( Important to note, UV-B irradiation, the atmospherically predominant UV radiation, has been shown to reduce the neuroprotective effects of riboflavin both in vitro and in vivo

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Once mixed, the solution can be stored in the refrigerator for a short time, but its best to use it as soon as possible to ensure maximum potency

FIGURE 1 Cocaine The World Drug Report estimates that worldwide, 18.8 million people used cocaine in 2014 (United Nations Office on Drugs and Crime, 2016)