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Discussion The results of this study show that either the acute- or short-term administration of the peripheral DBH inhibitor, etamicastat, decreases blood pressure in both non-anesthetized and anesthetized mice with germ line deletion of Drd2 or renal-selective silencing of Drd2 (renal subcapsular infusion of Drd2 siRNA in D 2 +/+ mice) but not in wild-type littermates or D 2 +/+ mice that received renal subcapsular infusion of non-silencing siRNA

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Studies show the peptide stimulates secretion of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) from hair follicle cells, with experimental formulations producing the most significant increases in these growth factors