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Ex vivo bronchial biopsies derived from asthma patients and human lung fibroblasts culture in vitro demonstrated apigenin (10, 20 M) attenuates TGF- induced fibroblast-to-myofibroblast transition, in a non-cytotoxic and non-cytostatic manner, potentially correlated with the inhibition of -smooth muscle actin and tenascin C expression [141]

Interestingly, lipid changes in the peripheral lipidome of PD patients also generally correspond with changes seen in the brain

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A new quiescent center appears from actively proliferating cells upon regeneration