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Under unstimulated conditions, ASK1 exists in a high-molecular-mass complex called the signalosome, which comprises an ASK1 homodimer and the reduced form of thioredoxin (Trx)

As expected from the Kepert model, in the absence of constraining ligands three coordinate complexes are trigonal planar

186 On the other hand, in a randomized controlled trial in 260 men with abnormal sperm number, motility, and morphology, 60 mg of saffron daily for 26 weeks resulted in no differences relative to placebo with regard to sperm density, motility, or morphology, or semen antioxidant capacity

In neither patient was there an unequivocal diagnosis, but one was considered to have a leukocytoclastic vasculitis, and the other, a severe desquamating syndrome that was considered variously to be a vasculitis or erythema multiforme