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The percentage of hemolysis was calculated using the following formula: Biocompatibility assay The major organs, including the heart, liver, spleen, lungs, and kidneys of the previous CIA mouse models, were harvested from the euthanized mice for further H&E staining and histology assay to evaluate the toxicity of MCMs, SP, and SP@M

Machine-learning approaches have demonstrated the capacity to analyze high-dimensional datasets linking NP physicochemical attributessuch as size, surface charge, lipid composition, ligand density, hydrophobicity, and structural topologywith their biological behavior in vivo, including hepatic tropism, immune recognition, complement activation, and endosomal escape efficiency [215,216,217,218]

It may lead to increased muscle mass via the promotion of protein synthesis

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