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Inhibition of necroptosis pathways with necrostatin-1 attenuated tissue damage and enhanced functional outcomes in the controlled cortical impact TBI model deficient in TNF- and Fas (You et al., 2008)

Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays