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& Westerterp-Plantenga, M

Thompson, D.H

demonstrated that heme oxygenase-1 (HO-1) in hUC-MSCs regulates autophagy and up-regulates CD8 + T cell cycling through activation of the c-Jun N-terminal kinase/ B-cell lymphoma 2 (JNK/Bcl-2) signaling pathway, which contributes to restoring ovarian function in POF mice [112]

For example, platinum (IV) prodrugs activated by intracellular GSH have demonstrated enhanced tumor selectivity and reduced systemic toxicity in clinical trials